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COX-2 inhibitor
COX-2 selective inhibitor is a form of non-steroidal anti-inflammatory drug (NSAID) that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX-2 reduces the risk of peptic ulceration, and is the main feature of celecoxib, rofecoxib and other members of this drug class. After several COX-2 inhibiting drugs were approved for marketing, data from clinical trials revealed that COX-2 inhibitors caused a significant increase in heart attacks and strokes, with some drugs in the class having worse risks than others. Rofecoxib (commonly known as Vioxx) was taken off the market in 2004 because of these concerns and celecoxib and traditional NSAIDs received boxed warnings on their labels.
==Medical uses==
Some COX-2 inhibitors are used in a single dose to treat pain after surgery.
Etoricoxib appears as good as if not better than other pain medications. Celecoxib appears to be about as useful as ibuprofen.
NSAIDs are often used in treatment of acute gout attacks. COX-2 inhibitors appear to work as well as nonselective NSAIDS. 〔 They have not been compared to other treatment options such as colchicine or glucocorticoids.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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